Alkaloids from Pilea Martinii (H.Lév) Hand-Mazz (Urticaceae) and Their Cytotoxic Activities

Authors: Doan Thi Thuy Ai, Trinh Thi Thanh Van, Doan Thi Mai Huong*, Marc Litaudon


Three alkaloids were isolated from the leaves of Pilea martinii (H.Lév) Hand-Mazz. Theirs structures were established by spectroscopic analysis including MS and NMR. Accordingly, the isolates were identified as 1,3,6,6-tetramethyl-5,6,7,8-tetrahydroisoquinolin-8-one (1), julandine (2), cryptopleurine (3). Compound 2 and 3 have shown potent cytotoxicity against four human tumor cell lines (KB, HepG2, MCF-7 and LU-1) with IC50 values of 0.07-0.26 µg/ml.


Pilea martinii (H.Lév) Hand-Mazz, Urticaceae, Julandine, Cryptopleurine, Cytotoxicity
Pages : 11-14

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