In recent years, the study of machine tool technology has got strong attention to expand development in universities, research institute and also in industry. However, there are a few publications/papers related a design and application of the multi-spindle drilling which flexibly adjusts parameters such as the number and the position of holes. In this research, the author will present a new design of a multi-spindle drilling head that uses Cardan universal joint for driving in order to increase productivity, decrease product expenses. To check the principle of working after simulation we developed a prototype of Multi-Spindle drilling head in this research.