Chemical constituents from fruit of Melia azedarach L. in Vietnam

Authors: Vũ Thị Hiền*, Nguyễn Ngọc Tuấn, Hoàng Văn Lựu, Vũ Đình Hoàng*

Abstract

Two flavonoids (apigenin, quercetin 3 - O -[α- L - rhamnopyranosyl - (1→6) - β- D-glucopyranoside]), a coumarin (scopoletin), a phenolic (vanilic acid), a triterpenoid (taraxerol), and two steroid (β-sitosterol and β-sitosterol-3-O-β-D-glucopyranoside) were isolated from the methanolic extract of the fruits of Melia azedarach L., using silica gel column chromatography methods. The structures of these compounds were elucidated using a combination of UV, IR, 1D and 2D NMR techniques (1H-, 13C-NMR, COSY, HSQC and HMBC), MS and HR-HS analyses, and the comparison with the literature data. This is the first isolation of these compounds from Melia azedarach growing in Viet Nam.

Keyword

Melia azedarach, Meliaceae, flavonoid, scopoletin, apigenin, taraxerol
Pages : 79-84

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