Avicennia marina (Forsk.) Vierh. (Verbenaceae) is a species of mangrove plant, distributed in the coastal mangrove forests of Northern and Southern Vietnam. Using combined chromatographic separations, three iridoid glucosides 2’-O-(4-methoxycinnamoyl)mussaenosidic acid (1), 2’-cinnamoyl-mussaenosidic acid (2), marinoid D (3), and a lignan glucoside syringaresinol-β-D-glucopyranoside (4) were isolated from the methanol extract of leaves of mangrove plant Avicennia marina. Structures of the isolated compounds were elucidated by spectroscopic methods including one dimesional (1D)- and (2D)- NMR, electrospray ionization mass spectrometry (ESI - MS), and also by comparison with the literature data. Compound 4 is reported for the first time from this plant.